Ovine Pulmonary Adenocarcinoma: A Unique Model to Improve Lung Cancer Research
نویسندگان
چکیده
منابع مشابه
Retrovirus-induced ovine pulmonary adenocarcinoma, an animal model for lung cancer.
Studies on the molecular mechanisms of transformation of retrovirus-induced neoplasms in domestic and laboratory animal species have provided insights into the genetic basis of cancer. Ovine pulmonary adenocarcinoma (OPA) is a retrovirus-induced spontaneous lung tumor of sheep that has striking analogies to some forms of human adenocarcinoma. The etiologic agent of OPA, jaagsiekte sheep retrovi...
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متن کاملUltrastructural study of naturally occuring ovine pulmonary adenocarcinoma in Fars province, Iran
Ovine pulmonary adenocarcinoma (OPA) was studied in the lungs of 15 naturally-affected sheep (9 with classical and 6 atypical lesions) by transmission electron microscopy. Two lung samples from normal sheep were used to develop the ultrastructural criteria. Pathologic lesions consisted of focal-multifocal to coalescent nodules or masses in the cranioventral or diaphragmatic lobes. Ultrastructur...
متن کاملDiagnosis and prevalence of ovine pulmonary adenocarcinoma in lung tissues of naturally infected farm sheep.
AIM This study was aimed to detect ovine pulmonary adenocarcinoma (OPA) in sheep flocks affected with pulmonary disorders at organized farm. MATERIALS AND METHODS A total of 75 sheep died naturally were thoroughly examined for the lesions of OPA during necropsy. Tissue sections from affected portion of the lungs from each animal were collected aseptically and divided into two parts; one each ...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2019
ISSN: 2234-943X
DOI: 10.3389/fonc.2019.00335